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| [00:05.49]Physical changes, such as gray hair and small lines on the face, appear as we grow older. [00:15.78]Now, American scientists say such changes may result partly from changes in our genetic material. [00:24.24]They say these genetic mutations increase over time as the cell-division process in our bodies begins to break down. [00:34.77]Researchers from the Scripps Research Institute in La Jolla, California, [00:41.56]reported the findings in the publication Science. [00:45.43]The researchers examined cells from four groups of people: [00:50.76]normal children, adults, very old people and children with a genetic condition called progeria. [01:01.65]Progeria causes the body to grow older at an extremely fast rate. [01:08.15]The researchers used a new technology to examine more than 6,000 genes at once. [01:16.88]They could see which genes were active among people in each age group. [01:23.91]They found that most of the genes kept the same level of activity in youth,middle age and old age. [01:34.04]However,the researchers identified sixty-one genes that speeded up or slowed down with age. [01:42.19]Richard Lerner of the Scripps InstitUte helped organize the study. [01:48.15]Mister Lerner says one-fourth of the sixty-one genes are what he calls quality control genes. [01:56.58]He says they are supposed to prevent cells from dividing if there are mistakes in the genetic material. [02:05.26]If the quality control genes work,then the genetic mutations are stopped immediately. [02:12.65]But sometimes the cells with genetic matatiofis produce new cells with the same mistakes, or worse one. [02:21.98]He says the increasing number of genetic mistakes in the cell-division process may cause signs of aging. |
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